Article
Neuropilin-2 axis in regulating secretory phenotype of neuroendocrine-like prostate cancer cells and its implication in therapy resistance.
Cell reports - 19 Jul 2022
Islam Ridwan, Mishra Juhi, Polavaram Navatha Shree, Bhattacharya Sreyashi, Hong Zhengdong, Bodas Sanika, Sharma Sunandini, Bouska Alyssa, Gilbreath Tyler, Said Ahmed M, Smith Lynette M, Teply Benjamin A, Muders Michael H, Batra Surinder K, Datta Kaustubh, Dutta Samikshan
Abstract excerpt
Neuroendocrine (NE)-like tumors secrete various signaling molecules to establish paracrine communication within the tumor milieu and to create a therapy-resistant environment. It is important to identify molecular mediators that regulate this secretory phenotype in NE-like cancer. The current study highlights the importance of a cell surface molecule, Neuropilin-2 (NRP2), for the secretory function of NE-like...
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