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Article

Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.

Human genetics - 1 May 2016

Enciso María, Sarasa Jonás, Xanthopoulou Leoni, Bristow Sara, Bowles Megan, Fragouli Elpida, Delhanty Joy, Wells Dagan

Abstract excerpt

MTHFR is an important enzyme in the metabolism of folic acid and is crucial for reproductive function. Variation in the sequence of MTHFR has been implicated in subfertility, but definitive data are lacking. In the present study, a detailed analysis of two common MTHFR polymorphisms (c.677C>T and c.1298A>C) was performed. Additionally, for the first time, the frequencies of different MTHFR alleles were assessed...

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Source

Identifiers

PMID: 27068821
DOI: 10.1007/s00439-016-1652-z

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Polymorphisms in the MTHFR gene influence embryo viability and the incidence of aneuploidy.PMID 27068821Read ↗

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