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Genomic characterization of undifferentiated sarcomatoid carcinoma of the pancreas.

Human pathology - 1 Oct 2022

Gkountakos Anastasios, Mafficini Andrea, Lou Emil, Malleo Giuseppe, Salvia Roberto, Calicchia Martina, Silvestris Nicola, Racila Emilian, Amin Khalid, Veronese Nicola, Brunetti Oronzo, Antonini Pietro, Ingravallo Giuseppe, Mattiolo Paola, Saponaro Concetta, Nappo Floriana, Simbolo Michele, Bariani Elena, Lonardi Sara, Fassan Matteo, Milella Michele, Lawlor Rita T, Scarpa Aldo, Luchini Claudio

Abstract excerpt

Undifferentiated sarcomatoid carcinoma (USC) of the pancreas is a rare but especially aggressive variant of pancreatic ductal adenocarcinoma (PDAC), composed of at least 80% of sarcomatoid cells. This study aimed to elucidate its clinicopathological and molecular features. The study cohort included 10 patients with pancreatic USC. Clinicopathological parameters were determined for each patient. The molecular...

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PMID: 35850360
DOI: 10.1016/j.humpath.2022.07.011

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