Metatypic Carcinoma of the Pancreas: Delineation of a Clinicopathologically Distinct Entity, Characterized by Centrally Necrotic Demarcated High-Grade Carcinoma With Divergent Patterns, Basal Immunophenotype, and Altered Molecular Profile.

doi:10.1097/PAS.0000000000002513

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Metatypic Carcinoma of the Pancreas: Delineation of a Clinicopathologically Distinct Entity, Characterized by Centrally Necrotic Demarcated High-Grade Carcinoma With Divergent Patterns, Basal Immunophenotype, and Altered Molecular Profile.

The American journal of surgical pathology - 1 Apr 2026

Atasoy Duygu, Saka Burcu, Armutlu Ayse, Mericoz Cisel A, Bagci Pelin, Balci Serdar, Tezcan Nuray, Bakkaloglu Irem G, Altinmakas Emre, Bozkurt Emre, Pehlivanoglu Burcin, Bozkurtlar Emine, Alper Emrah, Luchini Claudio, Mafficini Andrea, Bevere Michele, Scarpa Aldo, Tellioglu Gurkan, Yilmaz Serpil, Bilge Orhan, Esmer Rohat, Cheng Jeanette D, Tarcan Zeynep, Basturk Olca, Reid Michelle D, Krasinskas Alyssa, Gurses Bengi, Adsay N Volkan

Abstract excerpt

A distinct type of pancreatic carcinoma (n=31; 6% of adenocarcinomas) is described, distinguished from conventional pancreatic ductal adenocarcinoma (PDAC) by: (1) solid/undifferentiated (sheet-like, stroma-poor) carcinomas lacking features of other entities (no osteoclasts, microsatellite stable, INI-1 retained, nonkeratinizing squamous <30%), often admixed with ordinary PDAC; (2) radiology/gross showing central...

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Identifiers

PMID: 41622468
DOI: 10.1097/PAS.0000000000002513

Genes

ARID1A
KRAS
CDKN2A
GATA6
SMAD4
TP53

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