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Article

Amelioration of SARS-CoV-2 infection by ANO6 phospholipid scramblase inhibition

1 Jul 2022

Abstract excerpt

As an enveloped virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) delivers its viral genome into host cells via fusion of the viral and cell membranes. Here, we show that ANO6/TMEM16F-mediated cell surface exposure of phosphatidylserine is critical for SARS-CoV-2 entry and that ANO6-selective inhibitors are effective against SARS-CoV-2 infections. Application of the SARS-CoV-2 Spike pseudotyped...

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Identifiers

PMID: 35839776
DOI: 10.1016/j.celrep.2022.111117

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