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Article

KRAS mutations as essential promoters of lymphangiogenesis via extracellular vesicles in pancreatic cancer.

The Journal of clinical investigation - 15 Jul 2022

Pirlog Radu, Calin George A

Abstract excerpt

Kirsten rat sarcoma virus (KRAS) gene mutations are present in more than 90% of pancreatic ductal adenocarcinomas (PDACs). KRASG12D is the most frequent alteration, promoting preneoplastic lesions and associating with a more aggressive phenotype. These tumors possess increased intratumoral lymphatic networks and frequent lymph node (LN) metastases. In this issue of the JCI, Luo, Li, et al. explored the...

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Share to Cell Line, Tumor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35838046
DOI: 10.1172/JCI161454
PMCID: PMC9282924

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