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Article

Endosomal Trafficking Bypassed by the RAB5B-CD109 Interplay Promotes Axonogenesis in KRAS-Mutant Pancreatic Cancer.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Dec 2024

Zhang Dingwen, Luo Yuming, Lin Yan, Fang Zhou, Zheng Hanhao, An Mingjie, Xie Qingyu, Wu Zhuo, Yu Chao, Yang Jiabin, Yu Min, Chen Changhao, Chen Rufu

Abstract excerpt

Perineural invasion (PNI) represents a unique biological feature associated with poor prognosis in pancreatic ductal adenocarcinoma (PDAC), especially in the presence of KRAS mutations. Extracellular vesicle (EV)-packaged circular RNAs (circRNAs) function as essential mediators of tumor microenvironment communication, triggering PDAC cell invasion and distant metastasis. However, the regulatory mechanisms of...

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Topics

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Proto-Oncogene Proteins p21(ras)

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Source

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Identifiers

PMID: 39488792
DOI: 10.1002/advs.202405092
PMCID: PMC11653710

Genes

CD109
KRAS
DSCAML1
RAB5B
RET
TRPV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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