Article
Detection and Quantification of ctDNA for Longitudinal Monitoring of Treatment in Non-Small Cell Lung Cancer Patients Using a Universal Mutant Detection Assay by Denaturing Capillary Electrophoresis.
Pathology oncology research : POR - 1 Jan 2022
Benesova Lucie, Ptackova Renata, Halkova Tereza, Semyakina Anastasiya, Svaton Martin, Fiala Ondrej, Pesek Milos, Minarik Marek
Abstract excerpt
Background: Observation of anticancer therapy effect by monitoring of minimal residual disease (MRD) is becoming an important tool in management of non-small cell lung cancer (NSCLC). The approach is based on periodic detection and quantification of tumor-specific somatic DNA mutation in circulating tumor DNA (ctDNA) extracted from patient plasma. For such repetitive testing, complex liquid-biopsy techniques...
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