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Liquid Biopsy for Disease Monitoring in Non-Small Cell Lung Cancer: The Link between Biology and the Clinic.

Cells - 28 Jul 2021

Fernandes Maria Gabriela O, Sousa Catarina, Pereira Reis Joana, Cruz-Martins Natália, Souto Moura Conceição, Guimarães Susana, Justino Ana, Pina Maria João, Magalhães Adriana, Queiroga Henrique, Marques José Agostinho, Machado José Carlos, Costa José Luís, Hespanhol Venceslau

Abstract excerpt

INTRODUCTION: Cell-free DNA (cfDNA) analysis offers a non-invasive method to identify sensitising and resistance mutations in advanced Non-Small Cell Lung Cancer (NSCLC) patients. Next-generation sequencing (NGS) of circulating free DNA (cfDNA) is a valuable tool for mutations detection and disease's clonal monitoring. MATERIAL AND METHODS: An amplicon-based targeted gene NGS panel was used to analyse 101 plasma...

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Identifiers

PMID: 34440680
DOI: 10.3390/cells10081912
PMCID: PMC8394732

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