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Article

APR-246 triggers ferritinophagy and ferroptosis of diffuse large B-cell lymphoma cells with distinct TP53 mutations.

Leukemia - 1 Sept 2022

Hong Yuheng, Ren Tianyuan, Wang Xiaoxuan, Liu Xia, Fei Yue, Meng Shen, Han Xu, Sun Cong, Shen Hongru, Li Lanfang, Qiu Lihua, Qian Zhengzi, Zhou Shiyong, Zhang Huilai, Wang Xianhuo

Abstract excerpt

TP53 mutations correlate with inferior survival in many cancers. APR-246 is a compound to shift mutant p53 and exhibits anti-cancer effects. Among its effects, APR-246 facilitates the binding of restored p53 mutants to target genes and their transcription. A set of 2464 DLBCL cases from multiple cohorts including our center, was integrated to identify the type and localization of TP53 mutations and clinical...

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Identifiers

PMID: 35835991
DOI: 10.1038/s41375-022-01634-w

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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