Article
The anti-cancer agent APR-246 can activate several programmed cell death processes to kill malignant cells.
Cell death and differentiation - 1 Apr 2023
Wang Zilu, Hu Huimin, Heitink Luuk, Rogers Kelly, You Yue, Tan Tao, Suen Connie Li Wai, Garnham Alex, Chen Hao, Lieschke Elizabeth, Diepstraten Sarah T, Chang Catherine, Chen Tianwei, Moujalled Diane, Sutherland Kate, Lessene Guillaume, Sieber Oliver M, Visvader Jane, Kelly Gemma L, Strasser Andreas
Abstract excerpt
Mutant TP53 proteins are thought to drive the development and sustained expansion of cancers at least in part through the loss of the wild-type (wt) TP53 tumour suppressive functions. Therefore, compounds that can restore wt TP53 functions in mutant TP53 proteins are expected to inhibit the expansion of tumours expressing mutant TP53. APR-246 has been reported to exert such effects in malignant cells and is...
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