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Article

FOXP1 is a Transcription Factor for the Alzheimer's Disease Risk Gene SORL1

1 Feb 2025

Abstract excerpt

Sortilin-related receptor 1 (SORL1) is a risk gene of Alzheimer's disease (AD), and some protein-truncating (PTV) and rare missense variants causing the loss of function of SORL1 contribute to AD pathogenesis. SORL1 is an endosomal receptor that interacts with multiple protein sorting complexes to facilitate the transport of various cargoes through the endolysosomal network (ELN). However, the regulatory...

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PMID: 39902677
DOI: 10.1111/jnc.70011

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