Article
Neuregulin 1 (8p12) and childhood-onset schizophrenia: susceptibility haplotypes for diagnosis and brain developmental trajectories.
Molecular psychiatry - 1 Feb 2007
Addington A M, Gornick M C, Shaw P, Seal J, Gogtay N, Greenstein D, Clasen L, Coffey M, Gochman P, Long R, Rapoport J L
Abstract excerpt
Childhood-onset schizophrenia (COS), defined as onset of psychosis by the age of 12, is a rare and malignant form of the illness, which may have more salient genetic influence. Since the initial report of association between neuregulin 1 (NRG1) and schizophrenia in 2002, numerous independent replications have been reported. In the current study, we genotyped 56 markers (54 single-nucleotide polymorphisms (SNPs)...
Topics
- Adolescent
- Age of Onset
- Brain
- Child
- Female
- Genetic Predisposition to Disease
- Haplotypes
- Humans
- Linkage Disequilibrium
- Magnetic Resonance Imaging
- Male