Article
Immunogenomic Landscape of Hematological Malignancies.
Cancer cell - 14 Sept 2020
Dufva Olli, Pölönen Petri, Brück Oscar, Keränen Mikko A I, Klievink Jay, Mehtonen Juha, Huuhtanen Jani, Kumar Ashwini, Malani Disha, Siitonen Sanna, Kankainen Matti, Ghimire Bishwa, Lahtela Jenni, Mattila Pirkko, Vähä-Koskela Markus, Wennerberg Krister, Granberg Kirsi, Leivonen Suvi-Katri, Meriranta Leo, Heckman Caroline, Leppä Sirpa, Nykter Matti, Lohi Olli, Heinäniemi Merja, Mustjoki Satu
Abstract excerpt
Understanding factors that shape the immune landscape across hematological malignancies is essential for immunotherapy development. We integrated over 8,000 transcriptomes and 2,000 samples with multilevel genomics of hematological cancers to investigate how immunological features are linked to cancer subtypes, genetic and epigenetic alterations, and patient survival, and validated key findings experimentally....
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