Article
Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns.
Leukemia - 1 Jul 2012
Moore A S, Faisal A, Gonzalez de Castro D, Bavetsias V, Sun C, Atrash B, Valenti M, de Haven Brandon A, Avery S, Mair D, Mirabella F, Swansbury J, Pearson A D J, Workman P, Blagg J, Raynaud F I, Eccles S A, Linardopoulos S
Abstract excerpt
Acquired resistance to selective FLT3 inhibitors is an emerging clinical problem in the treatment of FLT3-ITD(+) acute myeloid leukaemia (AML). The paucity of valid pre-clinical models has restricted investigations to determine the mechanism of acquired therapeutic resistance, thereby limiting the development of effective treatments. We generated selective FLT3 inhibitor-resistant cells by treating the...
Topics
- Animals
- Apoptosis
- Aurora Kinases
- Benzenesulfonates
- Benzothiazoles
- Blotting, Western
- Cell Cycle
- Cell Proliferation
- Drug Resistance, Neoplasm
- Female