Article
Zika virus-like particle vaccine fusion loop mutation increases production yield but fails to protect AG129 mice against Zika virus challenge.
PLoS neglected tropical diseases - 1 Jul 2022
Thompson Danielle, Guenther Ben, Manayani Darly, Mendy Jason, Smith Jonathan, Espinosa Diego A, Harris Eva, Alexander Jeff, Vang Lo, Morello Christopher S
Abstract excerpt
Zika virus (ZIKV) is a mosquito-borne flavivirus with maternal infection associated with preterm birth, congenital malformations, and fetal death, and adult infection associated with Guillain-Barré syndrome. Recent widespread endemic transmission of ZIKV and the potential for future outbreaks necessitate the development of an effective vaccine. We developed a ZIKV vaccine candidate based on virus-like-particles...
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