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A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

6 Feb 2017

Abstract excerpt

A purified inactivated vaccine (PIV) using the Zika virus (ZIKV) Puerto Rico strain PRVABC59 showed efficacy in monkeys, and is currently in a phase I clinical trial. High-yield manufacture of this PIV is essential for its development and vaccine access. Here we report an infectious cDNA clone-launched platform to maximize its yield. A single NS1 protein substitution (K265E) was identified to increase ZIKV...

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Identifiers

PMID: 28196656
DOI: 10.1016/j.ebiom.2017.02.003

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