Article
Pro106Leu MPL mutation is associated with thrombocytosis and a low risk of thrombosis, splenomegaly and marrow fibrosis.
Platelets - 17 Nov 2022
Alzahrani Musa, Al Turki Saeed, Al Rajban Waleed, Alshalati Fatimah, Almodaihsh Fahad, Abuelgasim Khadega A, Alahmari Bader, Al Bogami Thamer, Ali Osama, Al Harbi Talal, AlBalwi Mohammed A, Alotaibi Maram, Aleem Aamer, Al Asker Ahmed, Al Mugairi Areej
Abstract excerpt
The P106L mutation in the human myeloproliferative leukemia virus oncogene (MPL) was shown to be associated with hereditary thrombocythemia in Arabs. The clinical and bone marrow (BM) features of P106L mutation are unknown. Genetic databases at two tertiary hospitals in Saudi Arabia were searched to identify patients with the MPL P106L mutation. Clinical data were collected retrospectively and the BM aspirates...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.