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Selfish centromeres and the wastefulness of human reproduction

5 Jul 2022

Abstract excerpt

Many human embryos die in utero owing to an excess or deficit of chromosomes, a phenomenon known as aneuploidy; this is largely a consequence of nondisjunction during maternal meiosis I. Asymmetries of this division render it vulnerable to selfish centromeres that promote their own transmission, these being thought to somehow underpin aneuploidy. In this essay, I suggest that these vulnerabilities provide only...

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PMID: 35788750
DOI: 10.1371/journal.pbio.3001671

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