Article
Association between mutational subgroups, Warburg-subtypes, and survival in patients with colorectal cancer.
Cancer medicine - 1 Jan 2023
Offermans Kelly, Jenniskens Josien C A, Simons Colinda C J M, Samarska Iryna, Fazzi Gregorio E, van der Meer Jaleesa R M, Smits Kim M, Schouten Leo J, Weijenberg Matty P, Grabsch Heike I, van den Brandt Piet A
Abstract excerpt
BACKGROUND: Previous research suggests that Warburg-subtypes are related to potentially important survival differences in colorectal cancer (CRC) patients. In the present study, we investigated whether mutational subgroups based on somatic mutations in RAS, BRAF, PIK3CA, and MET, which are known to promote the Warburg-effect, as well as mismatch repair (MMR) status, hold prognostic value in CRC. In addition, we...
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