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Associations of UDP-glucuronosyltransferases polymorphisms with mycophenolate mofetil pharmacokinetics in Chinese renal transplant patients.

Acta pharmacologica Sinica - 1 May 2015

Xie Xiao-chun, Li Jun, Wang Hong-yang, Li Hong-liang, Liu Jing, Fu Qian, Huang Jia-wen, Zhu Chen, Zhong Guo-ping, Wang Xue-ding, Sun Ping-ping, Huang Min, Wang Chang-xi, Li Jia-li

Abstract excerpt

AIM: To evaluate the effects of UDP-glucuronosyltransferases (UGTs) polymorphisms on the pharmacokinetics of the immunosuppressant mycophenolate mofetil (MMF) in Chinese renal transplant recipients. METHODS: A total of 127 renal transplant patients receiving MMF were genotyped for polymorphisms in UGT1A9 -1818T>C, I399C>T, -118T9/10, -440C>T, -331T>C, UGT2B7 IVS1+985A>G, 211G>T, -900A>G, UGT1A8 518C>G and UGT1A7...

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Identifiers

PMID: 25864649
DOI: 10.1038/aps.2015.7
PMCID: PMC4422949

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