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Article

Joint analysis of WES and RNA-Seq identify signature genes related to metastasis in prostate cancer.

Journal of cellular and molecular medicine - 1 Jul 2023

Xiang Chongjun, Li Yue, Wang Wenting, Tao Huiying, Liang Ning, Wu Shuang, Yu Tianxi, Cui Xin, Xie Yaqi, Zuo Hongwei, Lin Chunhua, Xu Fuyi

Abstract excerpt

Prostate cancer (PCa) has a certain degree of heritability, and metastasis occurs as cancer progresses. However, its underlying mechanism remains largely unknown. We sequenced four cases of cancer without metastasis, four metastatic cancer, and four benign hyperplasia tissues as controls. A total of 1839 damaging mutations were identified. Pathway analysis, gene clustering, and weighted gene co-expression network...

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PMID: 37378426
DOI: 10.1111/jcmm.17781
PMCID: PMC10339098

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