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Genome-scale CRISPR–Cas9 screen reveals novel regulators of B7-H3 in tumor cells

1 Jun 2022

Abstract excerpt

BACKGROUND: Despite advances in B7 homolog 3 protein (B7-H3) based immunotherapy, the development of drug resistance remains a major clinical concern. The heterogeneity and emerging loss of B7-H3 expression are the main causes of drug resistance and treatment failure in targeted therapies, which reveals an urgent need to elucidate the mechanism underlying the regulation of B7-H3 expression. In this study, we...

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PMID: 35768165
DOI: 10.1136/jitc-2022-004875

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