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A broad and potent neutralization epitope in SARS-related coronaviruses

29 Jun 2022

Abstract excerpt

Many neutralizing antibodies (nAbs) elicited to ancestral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) through natural infection and vaccination have reduced effectiveness to SARS-CoV-2 variants. Here, we show that therapeutic antibody ADG20 is able to neutralize SARS-CoV-2 variants of concern (VOCs) including Omicron (B.1.1.529) as well as other SARS-related coronaviruses. We delineate the...

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PMID: 35767670
DOI: 10.1073/pnas.2205784119

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