Article
Mutations in the miR-142 gene are not common in myeloproliferative neoplasms.
Scientific reports - 28 Jun 2022
Galka-Marciniak Paulina, Kanduła Zuzanna, Tire Adrian, Wegorek Wladyslaw, Gwozdz-Bak Kinga, Handschuh Luiza, Giefing Maciej, Lewandowski Krzysztof, Kozlowski Piotr
Abstract excerpt
Recent data indicate that MIR142 is the most frequently mutated miRNA gene and one of the most frequently mutated noncoding elements in all cancers, with mutations occurring predominantly in blood cancers, especially diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma. Functional analyses show that the MIR142 alterations have profound consequences for lympho- and myelopoiesis. Furthermore, one of the...
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