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Article

Serum levels of mature microRNAs in DICER1-mutated pleuropulmonary blastoma

10 Feb 2014

Abstract excerpt

DICER1 is a critical gene in the biogenesis of mature microRNAs, short non-coding RNAs that derive from either -3p or -5p precursor microRNA strands. Germline mutations of DICER1 are associated with a range of human malignancies, including pleuropulmonary blastoma (PPB). Additional somatic 'hotspot' mutations in the microRNA processing ribonuclease IIIb (RNase IIIb) domain of DICER1 are reported in cancer, and...

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PMID: 24513630
DOI: 10.1038/oncsis.2014.1

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