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Characterization of a thermostable Cas13 enzyme for one-pot detection of SARS-CoV-2

28 Jun 2022

Abstract excerpt

Type VI CRISPR-Cas systems have been repurposed for various applications such as gene knockdown, viral interference, and diagnostics. However, the identification and characterization of thermophilic orthologs will expand and unlock the potential of diverse biotechnological applications. Herein, we identified and characterized a thermostable ortholog of the Cas13a family from the thermophilic organism...

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PMID: 35763567
DOI: 10.1073/pnas.2118260119

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