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Article

Associations of the A118G OPRM1 polymorphism with sociotropy and interpersonal sensitivity.

Brain and behavior - 1 Jul 2022

Suzuki Akihito, Shirata Toshinori, Noto Keisuke, Matsumoto Yoshihiko, Muraosa Haruka, Abe Mio, Goto Kaoru, Otani Koichi

Abstract excerpt

BACKGROUND: The μ-opioid receptor (MOR) plays an important role in social bonding behaviors, while it is implicated in the pathophysiology of depression. It is shown that the A118G polymorphism (rs1799971) of the MOR gene (OPRM1) causes amino-acid exchange from Asn to Asp, and that this polymorphism is associated with altered mu-opioid receptor function. Meanwhile, sociotropy/autonomy and interpersonal...

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Identifiers

PMID: 35761357
DOI: 10.1002/brb3.2674
PMCID: PMC9304853

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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