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HIV Replication Under High-Level Cabotegravir Is Associated with the Appearance of 3'-PPT Mutations, Circular DNA Transcription and Recombination.

Viruses - 30 Nov 2024

Wei Xierong, Lipscomb Jonathan T, Tino Ariana Santos, Cong Mian-Er, Ruone Susan, Bentz Meghan L, Sheth Mili, Garcia-Lerma Gerardo, Johnson Jeffrey A

Abstract excerpt

The HIV integrase inhibitor, dolutegravir (DTG), in the absence of eliciting integrase (int) resistance, has been reported to select mutations in the virus 3'-polypurine tract (3'-PPT) adjacent to the 3'-LTR U3. An analog of DTG, cabotegravir (CAB), has a high genetic barrier to drug resistance and is used in formulations for treatment and long-acting pre-exposure prophylaxis. We examined whether mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39772184
DOI: 10.3390/v16121874

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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