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Article

A generalizable data-driven multicellular model of pancreatic ductal adenocarcinoma.

GigaScience - 1 Jul 2020

Aguilar Boris, Gibbs David L, Reiss David J, McConnell Mark, Danziger Samuel A, Dervan Andrew, Trotter Matthew, Bassett Douglas, Hershberg Robert, Ratushny Alexander V, Shmulevich Ilya

Abstract excerpt

BACKGROUND: Mechanistic models, when combined with pertinent data, can improve our knowledge regarding important molecular and cellular mechanisms found in cancer. These models make the prediction of tissue-level response to drug treatment possible, which can lead to new therapies and improved patient outcomes. Here we present a data-driven multiscale modeling framework to study molecular interactions between...

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Identifiers

PMID: 32696951
DOI: 10.1093/gigascience/giaa075
PMCID: PMC7374045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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