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Mechanism of drug resistance of BVDV induced by F224S mutation in RdRp: A case study of VP32947.

Computational biology and chemistry - 1 Aug 2022

He Dian, Li Xuedong, Wang Songsong, Wang Chengzhao, Liu Xingang, Zhang Yang, Cui Yan, Yu Sijiu

Abstract excerpt

Bovine viral diarrhea virus (BVDV) is an enveloped virus with an RNA genome, causing serious economic losses to the areas dominated by livestock industry. Currently, although several compounds with biological activities of inhibiting virus replication have been reported, amino acid mutations (especially F224S mutation) frequently occurring in the RNA-dependent RNA polymerase (RdRp) have greatly reduce their value...

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Antiviral Agents
Diarrhea Viruses, Bovine Viral
Drug Resistance
Indoles
Molecular Docking Simulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Dependent RNA Polymerase

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PMID: 35751995
DOI: 10.1016/j.compbiolchem.2022.107715

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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