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Binding properties of selective inhibitors of P323L mutated RdRp of SARS-CoV-2: a combined molecular screening, docking and dynamics simulation study.

Journal of biomolecular structure & dynamics - 1 May 2024

Chinnamadhu Archana, Ramakrishnan Jaganathan, Suresh Suganya, Poomani Kumaradhas

Abstract excerpt

Since 2019 the SARS-CoV-2 and its variants caused COVID-19, such incidents brought the world in pandemic situation. This happened due to furious mutations in SARS-CoV-2, in which some variants had high transmissibility and infective, this led the virus emerged as virulent and worsened the COVID-19 situation. Among the variants, P323L is one of the important mutants of RdRp in SARS-CoV-2. To inhibit the erroneous...

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PMID: 37301607
DOI: 10.1080/07391102.2023.2219762

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