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Article

Understanding the drug resistance mechanism of hepatitis C virus NS5B to PF-00868554 due to mutations of the 423 site: a computational study.

Molecular bioSystems - 1 Apr 2014

Jiao Pingzu, Xue Weiwei, Shen Yulin, Jin Nengzhi, Liu Huanxiang

Abstract excerpt

NS5B, a hepatitis C virus (HCV) RNA-dependent RNA polymerase (RdRp) that plays a key role in viral replication, is an important target in the discovery of antiviral agents. PF-00868554 is a potent non-nucleoside inhibitor (NNI) that binds to the Thumb II allosteric pocket of NS5B polymerase and has shown significant promise in phase II clinical trials. Unfortunately, several PF-00868554 resistant mutants have...

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PMID: 24452008
DOI: 10.1039/c3mb70498j

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