Article
Construction of a Multitissue Cell Atlas Reveals Cell-Type-Specific Regulation of Molecular and Complex Phenotypes in Pigs.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Feb 2026
Chen Lijuan, Li Houcheng, Teng Jinyan, Wang Zhen, Qu Xiaolu, Chen Zhe, Cai Xiaodian, Zeng Haonan, Bai Zhonghao, Li Jinghui, Pan Xiangchun, Yan Leyan, Wang Fei, Lin Lin, Luo Yonglun, Sahana Goutam, Lund Mogens Sandø, Ballester Maria, Crespo-Piazuelo Daniel, Karlskov-Mortensen Peter, Fredholm Merete, Clop Alex, Amills Marcel, Loving Crystal, Tuggle Christopher K, Madsen Ole, Li Jiaqi, Zhang Zhe, Liu George E, Jiang Jicai, Fang Lingzhao, Yi Guoqiang
Abstract excerpt
The systematic characterization of cellular heterogeneity among tissues and cell-type-specific regulation underlying complex phenotypes remains elusive in pigs. Within the Pig Genotype-Tissue Expression (PigGTEx) project, this work presents a single-cell transcriptome atlas of adult pigs encompassing 229 268 high-quality nuclei from 19 tissues, annotated to 67 major cell types. Besides cellular heterogeneity...
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