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APOBEC Alteration Contributes to Tumor Growth and Immune Escape in Pan-Cancer

8 Jun 2022

Abstract excerpt

The accumulating evidence demonstrates that the apolipoprotein B mRNA editing enzyme catalytic polypeptide-like (APOBEC), DNA-editing protein plays an important role in the molecular pathogenesis of cancer. In particular, the APOBEC3 family was shown to induce tumor mutations by an aberrant DNA editing mechanism. However, knowledge regarding the reconstitution of the APOBEC family genes across cancer types is...

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PMID: 35740493
DOI: 10.3390/cancers14122827

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