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Ontogenic Identification and Analysis of Mesenchymal Stromal Cell Populations during Mouse Limb and Long Bone Development.

Stem cell reports - 10 Oct 2017

Nusspaumer Gretel, Jaiswal Sumit, Barbero Andrea, Reinhardt Robert, Ishay Ronen Dana, Haumer Alexander, Lufkin Thomas, Martin Ivan, Zeller Rolf

Abstract excerpt

Bone-derived mesenchymal stromal cells (MSCs) differentiate into multiple lineages including chondro- and osteogenic fates and function in establishing the hematopoietic compartment of the bone marrow. Here, we analyze the emergence of different MSC types during mouse limb and long bone development. In particular, PDGFRαposSCA-1pos (PαS) cells and mouse skeletal stem cells (mSSCs) are detected within the...

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Identifiers

PMID: 28919259
DOI: 10.1016/j.stemcr.2017.08.007
PMCID: PMC5639212

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MSC

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