Article
Monocyte proinflammatory phenotypic control by ephrin type A receptor 4 mediates neural tissue damage.
JCI insight - 8 Aug 2022
Kowalski Elizabeth A, Soliman Eman, Kelly Colin, Basso Erwin Kristobal Gudenschwager, Leonard John, Pridham Kevin J, Ju Jing, Cash Alison, Hazy Amanda, de Jager Caroline, Kaloss Alexandra M, Ding Hanzhang, Hernandez Raymundo D, Coleman Gabe, Wang Xia, Olsen Michelle L, Pickrell Alicia M, Theus Michelle H
Abstract excerpt
Circulating monocytes have emerged as key regulators of the neuroinflammatory milieu in a number of neuropathological disorders. Ephrin type A receptor 4 (Epha4) receptor tyrosine kinase, a prominent axon guidance molecule, has recently been implicated in the regulation of neuroinflammation. Using a mouse model of brain injury and a GFP BM chimeric approach, we found neuroprotection and a lack of significant...
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