Article
A sensitive and inexpensive high-resolution melting-based testing algorithm for diagnosis of transient abnormal myelopoiesis and myeloid leukemia of Down syndrome.
Pediatric blood & cancer - 1 Nov 2022
Camargo Ricardo, de Castro Moreira Dos Santos Agenor, Cândido Guido Bruna, Lemos Mendanha Cavalcante Larissa, Silva Dias Anna Carolina, Mendonça de Pontes Robéria, Magalhães Furtado Felipe, Feitosa Salviano Cristiane, Tiziani Valdenize, Martins Córdoba José Carlos, Quezado Magalhães Isis Maria
Abstract excerpt
Patients with Down syndrome (DS) are commonly affected by a pre-leukemic disorder known as transient abnormal myelopoiesis (TAM). This condition usually undergoes spontaneous remission within the first 2 months after birth; however, in children under 5, 20%-30% of cases evolve to myeloid leukemia of Down syndrome (ML-DS). TAM and ML-DS are caused by co-operation between trisomy 21 and acquired mutations in the...
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