Article
Does genetic predisposition modify the effect of lifestyle-related factors on DNA methylation?
Epigenetics - 1 Dec 2022
Yu Chenglong, Hodge Allison M, Wong Ee Ming, Joo Jihoon E, Makalic Enes, Schmidt Daniel F, Buchanan Daniel D, Severi Gianluca, Hopper John L, English Dallas R, Giles Graham G, Milne Roger L, Southey Melissa C, Dugué Pierre-Antoine
Abstract excerpt
Lifestyle-related phenotypes have been shown to be heritable and associated with DNA methylation. We aimed to investigate whether genetic predisposition to tobacco smoking, alcohol consumption, and higher body mass index (BMI) moderates the effect of these phenotypes on blood DNA methylation. We calculated polygenic scores (PGS) to quantify genetic predisposition to these phenotypes using training (N = 7,431) and...
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