Article
Integrated proteomics, phosphoproteomics and metabolomics analyses reveal similarities among giant cell granulomas of the jaws with different genetic mutations.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 Aug 2022
Vitório Jéssica Gardone, Duarte-Andrade Filipe Fideles, Pereira Thais Dos Santos Fontes, Melo-Braga Marcella Nunes, Canuto Gisele André Baptista, Macedo Adriana Nori de, Lebron Yuri Abner Rocha, Moreira Victor Rezende, Felicori Liza Figueiredo, Lange Liséte Celina, Santos Lucilaine Valéria de Souza, Larsen Martin R, Gomes Carolina Cavalieri, Gomez Ricardo Santiago
Abstract excerpt
BACKGROUND: Giant cell granuloma of the jaws are benign osteolytic lesions of the jaws. These lesions are genetically characterized by mutually exclusive somatic mutations at TRPV4, KRAS, and FGFR1, and a fourth molecular subgroup which is wild-type for the three mutations. Irrespective of the molecular background, giant cell granulomas show MAPK/ERK activation. However, it remains unclear if these mutations lead...
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