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KRAS mutations in implant-associated peripheral giant cell granuloma.

Oral diseases - 1 Mar 2020

Martins-Chaves Roberta Rayra, Guimarães Letícia Martins, Pereira Thaís Dos Santos Fontes, Pereira Núbia Braga, Chrcanovic Bruno Ramos, Fonseca Felipe Paiva, Lafuente-Ibáñez de Mendoza Irene, Aguirre-Urizar José Manuel, Gomes Carolina Cavaliéri, Gomez Ricardo Santiago

Abstract excerpt

OBJECTIVES: To investigate the molecular pathogenesis of implant-associated peripheral giant cell granuloma (IA-PGCG). METHODS: A convenience sample of 15 IA-PGCG cases was selected. Hotspot mutations of KRAS, FGFR1, and TRPV4 genes, previously reported in conventional giant cell lesions of the jaws, were investigated by Sanger sequencing. As these mutations could activate MAPK/ERK pathway, the expression of...

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PMID: 31758745
DOI: 10.1111/odi.13241

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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