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Article

The Causal Effect of Systolic Blood Pressure Lowering on Vascular Outcomes in Diabetes: A Mendelian Randomization Study.

The Journal of clinical endocrinology and metabolism - 18 Aug 2022

Hou Tianzhichao, Li Mian, Lin Hong, Zhao Zhiyun, Lu Jieli, Wang Tiange, Xu Yu, Wang Weiqing, Bi Yufang, Ning Guang, Xu Min

Abstract excerpt

CONTEXT: The effect of lowering systolic blood pressure (SBP) on clinical outcomes in diabetic patients is controversial. OBJECTIVE: We used 2-sample mendelian randomization (MR) to study the causal effect of decreasing SBP on the risk of macrovascular and microvascular outcomes in diabetic patients. METHODS: We used 362 SBP-related genetic variants from a large genome-wide association study (n = 299 024) and UK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 35703944
DOI: 10.1210/clinem/dgac354

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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