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Article

Three-nucleotide periodicity of nucleotide diversity in a population enables the identification of open reading frames.

Briefings in bioinformatics - 18 Jul 2022

Jiang Mengyun, Ning Weidong, Wu Shishi, Wang Xingwei, Zhu Kun, Li Aomei, Li Yongyao, Cheng Shifeng, Song Bo

Abstract excerpt

Accurate prediction of open reading frames (ORFs) is important for studying and using genome sequences. Ribosomes move along mRNA strands with a step of three nucleotides and datasets carrying this information can be used to predict ORFs. The ribosome-protected footprints (RPFs) feature a significant 3-nt periodicity on mRNAs and are powerful in predicting translating ORFs, including small ORFs (sORFs), but the...

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Identifiers

PMID: 35698834
DOI: 10.1093/bib/bbac210
PMCID: PMC9294425

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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