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Article

Generation of a Human Deafness Sheep Model Using the CRISPR/Cas System.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022

Crispo Martina, Chenouard Vanessa, Dos Santos-Neto Pedro, Tesson Laurent, Souza-Neves Marcela, Heslan Jean-Marie, Cuadro Federico, Anegón Ignacio, Menchaca Alejo

Abstract excerpt

CRISPR/Cas9 system is a promising method for the generation of human disease models by genome editing in non-conventional experimental animals. Medium/large-sized animals like sheep have several advantages to study human diseases and medicine. Here, we present a protocol that describes the generation of an otoferlin edited sheep model via CRISPR-assisted single-stranded oligodinucleotide-mediated...

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PMID: 35696036
DOI: 10.1007/978-1-0716-2301-5_12

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