Article
Using Mendelian randomization to evaluate the causal relationship between serum C-reactive protein levels and age-related macular degeneration.
European journal of epidemiology - 1 Feb 2020
Han Xikun, Ong Jue-Sheng, An Jiyuan, Hewitt Alex W, Gharahkhani Puya, MacGregor Stuart
Abstract excerpt
Serum C-reactive protein (CRP), an important inflammatory marker, has been associated with age-related macular degeneration (AMD) in observational studies; however, the findings are inconsistent. It remains unclear whether the association between circulating CRP levels and AMD is causal. We used two-sample Mendelian randomization (MR) to evaluate the potential causal relationship between serum CRP levels and AMD...
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