Article
Whole-Genome Amplification-Surveying Yield, Reproducibility, and Heterozygous Balance, Reported by STR-Targeting MIPs.
International journal of molecular sciences - 31 May 2022
Raz Ofir, Tao Liming, Biezuner Tamir, Marx Tzipy, Neumeier Yaara, Tumanyan Narek, Shapiro Ehud
Abstract excerpt
Whole-genome amplification is a crucial first step in nearly all single-cell genomic analyses, with the following steps focused on its products. Bias and variance caused by the whole-genome amplification process add numerous challenges to the world of single-cell genomics. Short tandem repeats are sensitive genomic markers used widely in population genetics, forensics, and retrospective lineage tracing. A...
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