Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The genetic polymorphisms of key genes in WNT pathway (LRP5 and AXIN1) was associated with osteoporosis susceptibility in Chinese Han population.

Endocrine - 1 Feb 2022

Cui Yongsheng, Hu Xinglv, Zhang Chen, Wang Kunzheng

Abstract excerpt

BACKGROUND: Genetic factors play a critical role in the pathogenesis of osteoporosis. The imbalance of WNT/β-catenin will cause the occurrence of osteoporosis. LRP5 and AXIN1 play an important role in the classical Wnt/β-catenin signaling pathway. Our study was aimed to determine the association between five candidate single nucleotide polymorphisms (SNPs) of LRP5 or AXIN1 and osteoporosis susceptibility in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axin Protein
Share to Case-Control Studies
Share to China

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Osteoporosis

Share to Polymorphism, Single Nucleotide

Share to Wnt Signaling Pathway

Source

Identifiers

PMID: 34590211
DOI: 10.1007/s12020-021-02866-z

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The genetic polymorphisms of key genes in WNT pathway (LRP5 and AXIN1) was associated with osteoporosis susceptibility in Chinese Han population.PMID 34590211Read ↗

A new discovery of genetic polymorphisms of important genes in WNT pathway (LPR5 and AXIN1) associated with osteoporosis susceptibility in Chinese Han populationSemantic proximity Read ↗

Associations between WNT signaling pathway-related gene polymorphisms and risks of osteoporosis development in Chinese postmenopausal women: a case-control study.Semantic proximity Read ↗

Case Control Association Study of WNT Signaling Pathway-related Genes and Osteoporosis Risk Among Chinese Postmenopausal WomenSemantic proximity Read ↗

Common polymorphism in the LRP5 gene may increase the risk of bone fracture and osteoporosis.Semantic proximity Read ↗

Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women.Semantic proximity Read ↗

The importance of the Wnt/β-catenin pathway and LRP5 protein in bone metabolism of postmenopausal women.Semantic proximity Read ↗

The relationship between LRP5 rs556442 and rs638051 polymorphisms and mutations and their influence on bone metabolism in postmenopausal Xinjiang women with type 2 diabetes.Semantic proximity Read ↗

Investigating the impact of Wnt pathway-related genes on biomarker and diagnostic model development for osteoporosis in postmenopausal femalesSemantic proximity Read ↗

Association of rs3736228 polymorphism in LRP5 gene with bone fracture and osteoporosis: a systematic review and updated meta-analysisSemantic proximity Read ↗

[Wnt signaling molecules related to osteoporosis].Semantic proximity Read ↗

Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study.Semantic proximity Read ↗

Primary Osteoporosis in Young Adults: Genetic Basis and Identification of Novel Variants in Causal GenesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.