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Article

The Clinical Landscape of NRAS- mutated Juvenile Myelomonocytic Leukemia-like Myeloproliferation Includes Children With Costello Syndrome.

Journal of pediatric hematology/oncology - 1 Apr 2023

Pabari Reena, Chun Kathy, Naqvi Ahmed

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is a rare, aggressive pediatric disorder characterized by pathologic myeloproliferation because of alterations in RAS pathway genes. NRAS -mutated JMML encompasses a broad range of clinical severity. Herein we describe 4 unique cases of NRAS -mutated JMML and JMML-like myeloproliferation, 2 with somatic mutations and 2 with germline mutations. These cases illustrate the...

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PMID: 35665722
DOI: 10.1097/MPH.0000000000002492

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