Article
Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.
Science (New York, N.Y.) - 9 Sept 2016
Mayers Jared R, Torrence Margaret E, Danai Laura V, Papagiannakopoulos Thales, Davidson Shawn M, Bauer Matthew R, Lau Allison N, Ji Brian W, Dixit Purushottam D, Hosios Aaron M, Muir Alexander, Chin Christopher R, Freinkman Elizaveta, Jacks Tyler, Wolpin Brian M, Vitkup Dennis, Vander Heiden Matthew G
Abstract excerpt
Tumor genetics guides patient selection for many new therapies, and cell culture studies have demonstrated that specific mutations can promote metabolic phenotypes. However, whether tissue context defines cancer dependence on specific metabolic pathways is unknown. Kras activation and Trp53 deletion in the pancreas or the lung result in pancreatic ductal adenocarinoma (PDAC) or non-small cell lung carcinoma...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.