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Article

Changes in classification of genetic variants in BRCA1 and BRCA2.

Archives of gynecology and obstetrics - 1 Feb 2018

Kast Karin, Wimberger Pauline, Arnold Norbert

Abstract excerpt

INTRODUCTION: Classification of variants of unknown significance (VUS) in the breast cancer genes BRCA1 and BRCA2 changes with accumulating evidence for clinical relevance. In most cases down-staging towards neutral variants without clinical significance is possible. METHODS: We searched the database of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC) for changes in classification of...

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Identifiers

PMID: 29302806
DOI: 10.1007/s00404-017-4631-2

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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